Molecular View of Human Anatomy
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Spring 2006 Schedule
Download: PDF | MS Doc
Jan 19 Course overview and introductions
Lecture:
Introduction to biological molecules – proteins.
Download 'Introduction to biological molecules – proteins.' lecture [PPT]
HMB
Practical:
Introduction to the Molecule of the Month (MOM) features
SD
Homework:
Read the MOM features on Myoglobin, DNA and Major Histocompatibility Complexes. Learn as much as you can about these molecules.
Jan 26 Fundamental principles of structural biology
Lecture:
Chemical Bonds and interactions in molecules. Primary, secondary, tertiary & quaternary structures of proteins.
Download 'Chemical Bonds and interactions in molecules' lecture [PPT]
Download 01/26/2006 Quiz Key [DOC]
HMB
Practical:
Introduction to RasMol. Making physical models using toobers.
Download 'Introduction to RasMol' Lecture [PPT]
Download 'RasMol Reference Guide' [DOC]
Download 'Using RasMol and making toober models' Practical [DOC]
HMB/SD
Homework:
Draw the most beautiful and informative picture of the molecules 1HSA and 1PSV using RasMol
Feb 02 Animation and visualization
Lecture:
Graphical Animations
DS
Practical:
Introduction to another visualization software: Chimera
Download 'Chimera Reference' [DOC]
JO
Homework:
Draw the most beautiful and informative picture of the same molecule 1HSA and 1PSV using Chimera

For 1HSA: Create a diagram using 1HSA that shows only chains A, B and C. Show chain C as an all atom representation, and chains A and B as ribbon diagrams. Add any additional colors, surfaces, etc. as you think helps make the picture more appealing or interesting.
Feb 09 X-ray crystallography
Lecture:
Introduction to X-ray crystallography
Download 'Introduction to X-ray crystallography' lecture [PPT]
HMB
Practical:
Symmetry
Download 'Symmetry Practical' [PPT]
HMB
Homework:
Make unit cell with assigned Escher drawing
Feb 16 Protein Data Bank (PDB)
Lecture:
Introduction to the RCSB PDB
Download 'Introduction to the RCSB PDB' lecture [PPT]
HMB
Practical:
Using the RCSB PDB website
Download 'Using the RCSB PDB web site' lecture [PPT]
Download 'Using the RCSB PDB web site' exercise [DOC]
Download 'Using the RCSB PDB web site' key [DOC]
SD
Homework:
Find molecules related to your favorite disease. Make a tabulated list PDB entries related to this disease, showing the PDB IDs and primary citation.
Feb 23 Human Digestive system
Lecture:
Introduction to the human Digestive system
(Anatomy, Physiology and Biochemistry)
Download 'Introduction to the human Digestive system' lecture [PPT]
JS
Homework:
Review the process of human digestion discussed in class. Make a list of 5 different molecules related to human digestion that are represented in the PDB. Make a tabulated list PDB entries related to this disease, showing the PDB IDs and primary citation for each molecule.
Mar 2 Molecular Anatomy Project (MAP)
Lecture:
Introduction to MAP
Download 'Exploring the MAP Website' lecture [PPT]
HMB/SD
Practical:
Setting up accounts and learning to use the MAP website
JD
Identify molecules for study/presentations.

Homework:
Create a MAP submission on Lysozyme

Mar 9 Other web-based resources
Lecture:
Analyzing printed matter based on scientific evidence
Other web-based resources for scientific research and learning
PubMed, Uniprot, GO, NCBI, OMIM, PDBSum
SD
Practical:
Exercise on using some of the resources discussed in class
SD
Homework:
Highlight provided text according to source, evidence and opinion codes

Mar 16 Spring Break
Mar 23 Example of a digestive disease
Lecture:
Celiac disease – molecules affected in the disease
Download 'Celiac Disease' lecture [PPT]
   Download 'Celiac Lecture Supplement 1' [PPT]
   Download 'Celiac Lecture Supplement 2' [PPT]
HMB
Practical:
The social aspects of Celiac disease
HMB
Homework:
Create a MAP submission on Celiac disease

Mar 30 MAP discussions
Lecture:
Presentation of Celiac disease submissions
HMB/SD
Apr 6 Student research
Apr 13 Student research
Apr 20 Project 1 presentations
Each student will give a 20 minute talk on their assigned digestive protein molecule.
See 'Project Information' for details.

Digestive Molecule student presentations available from the student information page.
Apr 27 Project 2 presentations
Each student will hand in a 10 page paper and give a 20 minute talk on their chosen disease and the molecules that are involved with that disease.
See 'Project Information' for details.

Disease student presentations available from the student information page.