Course Summary

This course will begin with a discussion of the underlying principles of biomacromolecular structure. It will then cover the various biophysical methods used to study the structures and dynamics of these molecules including x-ray crystallography, NMR spectroscopy, calorimetry, mass spectroscopy as well computational methods. Finally the methods for studying enzyme kinetics and protein-ligand binding will be discussed.

Case studies involving key biological macromolecules will be used to highlight the principles and methods. The course is designed to enable students to be able to read and understand advanced research papers in biophysical chemistry and to use various bioinformatics resources including the Protein Data Bank.

This course is open to graduate students in Chemistry, Molecular Biosciences, and BIOMAPS.